St Thomas University Health & Medical Paper

For this assignment, you will write a paper on the pharmacological management of the disease. The paper should include:

A review of the selected disease process that is of interest to you.

A/An review/overview of the pathophysiology of the disease state.

  • A review of the pharmacological agents used for treatment and important information related to advanced practice nurse.
  • The title of your paper must be in the format of the following sample. Sample title: “Pharmacological Effects of Anti-Hypertensive Medications in the Management of Hypertension”.

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The pharmacological management of various diseases plays a pivotal role in the field of medicine. Understanding the pathophysiology of a disease and the pharmacological agents used for treatment is vital for healthcare professionals, especially advanced practice nurses. In this paper, we will explore the pharmacological management of a selected disease, including a review and overview of the disease process and its pathophysiology. Additionally, we will discuss the pharmacological agents used for treatment, focusing on important information relevant to advanced practice nurses.

The disease process selected for this paper is hypertension, commonly known as high blood pressure. Hypertension affects millions of individuals worldwide and is a significant risk factor for various cardiovascular diseases, including heart attacks and stroke.

The pathophysiology of hypertension involves increased systemic vascular resistance, leading to elevated blood pressure levels. This can result from factors such as increased sympathetic nervous system activity, renin-angiotensin-aldosterone system activation, endothelial dysfunction, and genetic predisposition.

The pharmacological management of hypertension involves a variety of drug classes targeted at different aspects of the pathophysiology. The most commonly used pharmacological agents for the treatment of hypertension include:

1. Angiotensin-Converting Enzyme (ACE) Inhibitors: These medications inhibit the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. ACE inhibitors, such as lisinopril and ramipril, are known to reduce systemic vascular resistance and help lower blood pressure levels.

2. Angiotensin II Receptor Blockers (ARBs): ARBs, like losartan and valsartan, work by blocking the effects of angiotensin II on blood vessels, resulting in vasodilation and decreased blood pressure.

3. Calcium Channel Blockers (CCBs): CCBs, such as amlodipine and verapamil, inhibit the entry of calcium into smooth muscle cells, leading to relaxation of blood vessels and reduced vascular resistance.

4. Diuretics: These medications, including hydrochlorothiazide and furosemide, increase the excretion of sodium and water from the body, thereby reducing blood volume and decreasing blood pressure.

5. Beta-Blockers: Beta-blockers, such as metoprolol and propranolol, block the effects of adrenaline on beta receptors in the heart and blood vessels, resulting in decreased heart rate, cardiac output, and blood pressure.

6. Direct Renin Inhibitors: Aliskiren is an example of a direct renin inhibitor that slows down the enzymatic activity of renin, thereby reducing the formation of angiotensin I and II and subsequently lowering blood pressure.

As an advanced practice nurse, it is crucial to consider important information related to these pharmacological agents for the effective management of hypertension. This includes understanding medication dosages, potential drug interactions, adverse effects, contraindications, and monitoring parameters. Additionally, advanced practice nurses should possess knowledge about patient education and counseling, ensuring medication adherence and lifestyle modifications for optimal blood pressure control.

In conclusion, the pharmacological management of hypertension involves a wide range of agents that target various aspects of the disease’s pathophysiology. Advanced practice nurses play a crucial role in the monitoring, prescribing, and education of patients undergoing treatment for hypertension, ensuring optimal management and reducing the risks associated with this prevalent condition. By understanding the disease process, pathophysiology, and pharmacological agents, advanced practice nurses can provide comprehensive care to individuals with hypertension.

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